Early Detection of Subclinical Atrial Flutter-Fibrillation in Patients with Unexplained Palpitation Using a Novel VDD Defibrillator with Integrated Atrial-Sensing Rings

Article information

Int J Arrhythm. 2016;17(3):163-166
Publication date (electronic) : 2016 September 30
doi : https://doi.org/10.18501/arrhythmia.2016.028
Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Correspondence: Seung-Jung Park, MD, PhD, Division of Cardiology, Department of Medicine, Heart, Vascular, and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea Tel: +82-2-3410-7145 FAX: +82-2-3410-3849 E-mail: orthovics@skku.edu, orthovics@gmail.com
Received 2016 September 16; Revised 2016 September 21; Accepted 2016 September 21.

Abstract

A 56-year-old man with an implantable cardioverter-defibrillator (ICD) presented with unexplained heart palpitations, which were usually aggravated after ingesting alcohol. He had a history of coronary artery bypass graft surgery 8 years ago, and an ICD was placed (i.e. a single ventricular shock coil with integrated atrial-sensing rings [VDD ICD lead]) 1.5 years ago for primary prevention of sudden cardiac death associated with ischemic cardiomyopathy. Repeated electrocardiograms and echocardiograms showed no evidence of atrial flutter-fibrillation; this was clearly demonstrated using several atrial electrogram strips during the ICD analysis.

Introduction

A significant proportion of patients who receive implantable cardioverter-defibrillators (ICDs) have a history of atrial fibrillation (AF) at the time of the initial procedure, or new-onset AF episodes during follow-up. In a subanalysis of the PainFree SmartShock® Technology study, new-onset AF was detected in approximately 22% of patients with ICDs in the first 12 months of follow-up [1,2]. Device-detected AF, even if asymptomatic, has been closely associated with an increased risk for stroke or systemic embolism [3,4]. In addition, subclinical AF has been detected in almost 30% of patients with cryptogenic stroke when continuously monitored using implantable cardiac devices [5]. We report the case of a patient with subclinical AF detected only after ICD analysis with integrated atrial-sensing rings.

Case

A 56-year-old man presented with several episodes of unexplained heart palpitations, which were usually aggravated one or two days after ingesting alcohol. He underwent coronary artery bypass graft surgery for three-vessel coronary artery disease eight years before presentation. Despite optimal medical treatment, the left ventricular ejection fraction gradually decreased to 19%. For the primary prevention of sudden cardiac death, an ICD was placed 18 months ago using a novel single-chamber VDD ICD (Iforia 7 VR-T DX®, Biotronik Inc., Berlin, Germany) and a single-coil active lead with integrated atrial sensing rings (Linoxsmart S DX®, Biotronik Inc., Berlin, Germany) (Figure 1). The VDD ICD was programmed to detect atrial tachyarrhythmia >200 beats per minute (bpm). Ventricular tachycardia zone settings were as follows; >162 bpm for monitoring alone, >182 bpm for anti-tachycardia pacing and shock, and >200 bpm for shock with 30~40 J.

Figure 1.

A single-coil active ICD lead with atrial-sensing rings (arrow) can be easily noted in chest X-ray (upper). Atrial (A) and ventricular (V) electrograms are well-correlated with P- and R-waves in far field (FF) electrograms (lower). ICD, implantable cardioverter-defibrillation.

A thorough review of the patient's medical records, multiple 12-lead electrocardiograms (ECGs) (recorded >20 times), and echocardiograms (performed >10 times) showed no evidence of atrial or ventricular tachyarrhythmic episodes (Figure 2). However, ICD analysis revealed multiple episodes of atrial flutter with 2:1 conduction, and AF with irregularly irregular RR intervals, which were clearly recorded in atrial and far-field electrograms (Figure 3). Moreover, some AF episodes lasted more than 4–10 hours. During the paroxysmal atrial flutter-fibrillation episodes, ventricular rates increased up to 200–210 bpm without triggering inappropriate shock or antitachycardia pacing.

Figure 2.

No evidence of atrial fibrillation was observed in repeated 12-lead electrocardiographic examinations. Q-waves in anteroseptal and inferior leads along with multiple suture wires in Figure 1 are compatible with a history of ischemic cardiomyopathy with 3-vessel coronary artery disease.

Figure 3.

A clear demonstration of atrial flutter with 2:1 conduction revealed after ICD analysis (upper). Atrial flutter degenerated into atrial fibrillation recorded in atrial electrogram and irregularly irregular RR interval shown in far field (FF) electrogrm (lower). ICD, implantable cardioverter-defibrillation.

The CHA₂DS₂-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke/transient ischemic attack [TIA], vascular disease, age 65–74 years, sex category) score of the patient was calculated and determined to be two, because of the patient's history of diabetes and heart failure; antiarrhythmic and anticoagulation therapies were initiated after confirming the presence of significant atrial flutter-fibrillation.

Discussion

The incidence of device-detected atrial tachyarrhythmia was reported in up to 50% of patients during a 2-year follow-up [16]. However, a significant proportion of those episodes may be silent (approximately 90%), increasing the risk for delayed anticoagulation therapy in patients with a high risk for stroke [7].

Detection of subclinical AF using a conventional single-chamber ICD system is quite limited. In addition, ICD recipients usually have several risk factors for stroke, including congestive heart failure, hypertension, old age, diabetes, and past history of systemic embolism. Using a dual-chamber ICD with an independent atrial lead may enhance the efficacy of AF detection; however, dual-chamber ICD placement is usually associated with higher costs, longer fluoroscopy and procedure time, and more complications, including pneumothorax, tamponade, hematoma, and lead dislodgement [8,9]. Moreover, using a dual-chamber ICD could make the subsequent lead extractions more difficult in case of ICD system infection [10].

A novel VDD ICD system with two integrated atrial rings mounted 15–18 cm from the single-coil defibrillation lead tip, can provide information on atrial rhythm and stored atrial electrograms. This additional information may be helpful in discriminating ventricular tachyarrhythmia from supraventricular tachycardia [8,11], or in the early detection of subclinical AF as shown in our case. Our patient did not show any evidence of AF during more than eight years of follow-up in multiple tests of 12-lead ECG and telemonitoring. Even with repeated echocardiograms (performed >10 times), transmitral E- and A-waves were always measured by pulsed-wave Doppler. Combined ECG recording during examination also revealed no AF rhythms. In patients with a high risk for stroke (CHA₂DS₂-VASc score, 2), optimal anticoagulation therapy may be greatly delayed if conventional ICD were placed. Therefore, this novel VDD ICD system with two integrated atrial sensing functions may be useful in better managing patients with silent AF, without increasing the complexity of an ICD procedure.

References

1. Wilke I, Witzel K, Münch J, Pecha S, Blankenberg S, Reichenspurner H, Willems S, Patten M, Aydin A. High incidence of De Novo and subclinical atrial fibrillation in patients with hypertrophic cardiomyopathy and cardiac rhythm management device. J Cardiovasc Electrophysiol 2016;27:779–842.
2. Schloss EJ, Auricchio A, Kurita T, Meijer A, Rogers T, Tejima T, Brown ML, Sterns LD. How Common is New Onset Atrial Fibrillation in Single Chamber ICD Patients? Sub-analysis From the PainFree SST Study. Circulation 2015;132(Suppl 3):A17946.
3. Lau CP, Siu CW, Yiu KH, Lee KL, Chan YH, Tse HF. Subclinical atrial fibrillation and stroke: insights from continuous monitoring by implanted cardiac electronic devices. Europace 2015;17(Suppl 2):ii40–46.
4. Healey JS, Connolly SJ, Gold MR, Israel CW, Van Gelder IC, Capucci A, Lau CP, Fain E, Yang S, Bailleul C, Morillo CA, Carlson M, Themeles E, Kaufman ES, Hohnloser SH. ASSERT Investigators. Subclinical atrial fibrillation and the risk of stroke. N Engl J Med 2012;366:120–129.
5. Brachmann J, Morillo CA, Sanna T, Di Lazzaro V, Diener HC, Bernstein RA, Rymer M, Ziegler PD, Liu S, Passman RS. Uncovering atrial fibrillation beyond short-term monitoring in cryptogenic stroke patients: three-year results from the cryptogenic stroke and underlying atrial fibrillation trial. Circ Arrhythm Electrophysiol 2016;9:e003333.
6. Glotzer TV, Hellkamp AS, Zimmerman J, Sweeney MO, Yee R, Marinchak R, Cook J, Paraschos A, Love J, Radoslovich G, Lee KL, Lamas GA. MOST Investigators. Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the atrial diagnostics ancillary study of the MOde Selection Trial (MOST). Circulation 2003;107:1614–1619.
7. Strickberger SA, Ip J, Saksena S, Curry K, Bahnson TD, Ziegler PD. Relationship between atrial tachyarrhythmias and symptoms. Heart Rhythm 2005;2:125–131.
8. Sticherling C, Zabel M, Spencker S, Meyerfeldt U, Eckardt L, Behrens S, Niehaus M. ADRIA Investigators. Comparison of a novel, single-lead atrial sensing system with a dual-chamber implantable cardioverter-defibrillator system in patients without antibradycardia pacing indications: results of a randomized study. Circ Arrhythm Electrophysiol 2011;4:56–63.
9. Dewland TA, Pellegrini CN, Wang Y, Marcus GM, Keung E, Varosy PD. Dual-chamber implantable cardioverter-defibrillator selection is associated with increased complication rates and mortality among patients enrolled in the NCDR implantable cardioverter-defibrillator registry. J Am Coll Cardiol 2011;58:1007–1013.
10. Kim JB. Successful extraction of an implantable cardioverter defibrillator lead in a patient with pocket infection via the femoral approach by using a basket snare. Int J Arrhythm 2012;13:44–48.
11. Friedman PA, McClelland RL, Bamlet WR, Acosta H, Kessler D, Munger TM, Kavesh NG, Wood M, Daoud E, Massumi A, Schuger C, Shorofsky S, Wilkoff B, Glikson M. Dual-chamber versus single-chamber detection enhancements for implantable defibrillator rhythm diagnosis: the detect supraventricular tachycardia study. Circulation 2006;113:2871–2879.

Biography

Seung-Jung Park, MD, PhD

Article information Continued

Figure 1.

A single-coil active ICD lead with atrial-sensing rings (arrow) can be easily noted in chest X-ray (upper). Atrial (A) and ventricular (V) electrograms are well-correlated with P- and R-waves in far field (FF) electrograms (lower). ICD, implantable cardioverter-defibrillation.

Figure 2.

No evidence of atrial fibrillation was observed in repeated 12-lead electrocardiographic examinations. Q-waves in anteroseptal and inferior leads along with multiple suture wires in Figure 1 are compatible with a history of ischemic cardiomyopathy with 3-vessel coronary artery disease.

Figure 3.

A clear demonstration of atrial flutter with 2:1 conduction revealed after ICD analysis (upper). Atrial flutter degenerated into atrial fibrillation recorded in atrial electrogram and irregularly irregular RR interval shown in far field (FF) electrogrm (lower). ICD, implantable cardioverter-defibrillation.